Medical Immunology
Volume 5
|
Viewing options:Associated material:Related literature:- Articles citing this article
- Other articles by authors
- Related articles/pages
Tools:Post to:
|
  ReviewChronic Granulomatous Disease; fundamental stages in our understanding of CGDTracy Assari Molecular Immunology Unit, The Institute of Child Health, University College London and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 3EH, UK Medical Immunology 2006,
5:4doi:10.1186/1476-9433-5-4
|
|
| Published: |
21 September 2006 |
Abstract
It has been 50 years since chronic granulomatous disease was first reported as a disease which fatally affected the ability of children to survive infections. Various milestone discoveries from the insufficient ability of patients' leucocytes to destroy microbial particles to the underlying genetic predispositions through which the disease is inherited have had important consequences. Longterm antibiotic prophylaxis has helped to fight infections associated with chronic granulomatous disease while the steady progress in bone marrow transplantation and the prospect of gene therapy are hailed as long awaited permanent treatment options. This review unearths the important findings by scientists that have led to our current understanding of the disease. | 
on Google Scholar
